Endocrine Abstracts

Neonatal hypocalcaemia (NH) is a well described phenomena with values of 2–2.25 mmol/l seen at 24 h of age after the cessation of transfer of transplancental calcium. Levels then increase to normal by 2 weeks of life. Calcium levels below 2.0 mmol/l in infants >1.5 kg is considered to be pathological hypocalcaemia. The role of vitamin D in NH is unclear and not well studied in both neonate and mother.Aim: To present the features of neonates with...

Introduction: Maternal thyroid disorders influence neonatal thyroid status. Neonatal thyrotoxicosis (NT) is a potentially fatal condition with high risk in those with clinical signs, high or unknown maternal thyroid receptor antibody (TRAb) status and where mother is clinically hyperthyroid or on treatment. The aim of post-natal management of these babies is to identify those at risk of NT and monitor them. There is, however, no available national or international consensus.</...

Background: Previous studies have reported that increased BMI and increase in insulin requirement are associated with more rapid disease progression following diagnosis in type 1 diabetes mellitus (T1DM). The recent UK National Paediatric Diabetes Audit (NPDA) 2013/14 reported that 37% of 0–11 year old children and 44% of 12 years and older children are currently overweight or obese.Objective: Our objective was to evaluate factors associated with in...

Background: Isolated prepubertal vaginal bleeding can be secondary to various causes including Mullerian cyst, papilloma, foreign body and prepubertal menarche. There is no current consensus on the investigations for prepubertal girls with isolated vaginal bleeding with no other signs of precocious puberty.Objective: The objective of our study is to evaluate the factors associated with persistent isolated cyclical vaginal bleeding including clinical pres...

Background: The Craniopharyngioma service in our centre has changed since 2005 with a standardised preoperative assessment and a new approach to surgery and use of radiotherapy. We review the subsequent outcomes.Treatment strategy: Preoperative endocrinology: prior to dexamethasone therapy: standard dose short synacthen test (SST), thyroid function test (TFT), IGF1, LH, FSH, testosterone/oestradiol±GH stimulation test. Staging: MRI and tumour stagin...